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Experience with long-term therapy with Danazol is limitedPeliosis hepatis and benign hepatic adenoma have been observed with long-term usePeliosis hepatis and hepatic adenoma may be silent until complicated by acutepotentially life-threatening intra-abdominal hemorrhageThe physician therefore should be alert to this possibilityAttempts should be made to determine the lowest dose that will provide adequate protectionIf the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to traumastress or other causeperiodic attempts to decrease or withdraw therapy should be considered.

4Porphyriadanazol can induce ALA synthetase activity and hence porphyrin metabolism.

Danazol is used to treat endometriosis and fibrocystic breast diseaseDanazol is also used to prevent attacks of angioedema in people with an inherited form of this disorderhereditary angioedema

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