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No dedicated pharmacokinetic study using colchicine capsules has been conducted in patients with varying degrees of hepatic impairmentColchicine is known to be metabolized in humans and the presence of severe hepatic impairment has been associated with colchicine toxicityHepatic clearance of colchicine may be significantly reduced and plasma half-life prolonged in patients with chronic hepatic impairment.

DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs interact differently in each personwe cannot guarantee that this information includes all possible interactionsThis cheap thyroid medication. information is not a substitute for medical adviceAlways speak with your healthcare provider about possible interactions with all prescription drugsvitaminsherbs and supplementsand over-the-counter drugs that you are taking.

Dose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe hepatic impairment.

DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs interact differently in each personwe cannot guarantee that this information includes all possible interactionsThis information is not a substitute for medical adviceAlways speak with your healthcare provider about possible interactions with all prescription drugsvitaminsherbs and supplementsand over-the-counter drugs that you are taking.

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colchicine, a drug first used to treat gout around 1500 b.

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