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The reconstituted solution may be stored for up to 24 hours at room temperature prior to intravenous infusion and does not need to be protected from light.

Literature suggests that concomitant use of PPIs with methotrexateprimarily at high dosesee methotrexate prescribing informationmay elevate and prolong serum levels of methotrexate and/or its metabolitepossibly leading to methotrexate toxicitiesIn high-dose methotrexate administrationa temporary withdrawal of the PPI may be considered in some patientssee Drug Interactions7

Hepatobiliary Disordershepatocellular damage leading to jaundice and hepatic failure.

Preparation and Administration Instructions for Pathological Hypersecretion Including Zollinger-Ellison Syndrome.

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