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Nephrolithiasis/urolithiasis has occurred with CRIXIVAN therapyThe cumulative frequency of nephrolithiasis is substantially higher in pediatric patients29than in adult patients12.4range across individual trials4.7to 34.4The cumulative frequency of nephrolithiasis events increases with increasing exposure to CRIXIVANhoweverthe risk over time remains relatively constantIn some casesnephrolithiasis/urolithiasis has been associated with renal insufficiency or acute renal failurepyelonephritis with or without bacteremiaIf signs or symptoms of nephrolithiasis/urolithiasis occurincluding flank painwith or without hematuria or microscopic hematuriatemporary interruptione.g13 daysor discontinuation of therapy may be consideredAdequate hydration is recommended in all patients treated with CRIXIVANSee ADVERSE REACTIONS and DOSAGE AND ADMINISTRATIONNephrolithiasis/Urolithiasis

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indinavir undergoes extensive metabolism by cytochrome p-450 cyp 3a4 isoenzymes to several metabolites the activity of which is unknown .

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