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Data from the high dose multifactorial trial see clinical studies provides estimates of the probability of reaching a target blood pressure with diovan hct compared to valsartan or hydrochlorothiazide monotherapy.

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Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretionbut the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of valsartan on blood pressure.

In the unusual case that there is no appropriate alternative to therapy with drugs affecting the reninangiotensin system for a particular patientapprise the mother of the potential risk to the fetusPerform serial ultrasound examinations to assess the intra-amniotic environmentIf oligohydramnios is observeddiscontinue Diovanunless it is considered lifesaving for the motherFetal testing may be appropriatebased on the week of pregnancyPatients and physicians should be awarehoweverthat oligohydramnios may not appear until after the fetus has sustained irreversible injuryClosely observe infants with histories of in utero exposure to Diovan for hypotensionoliguriaand hyperkalemiasee Pediatric Use

If a child taking valsartan cannot swallow a capsule wholeyour pharmacist can mix the medicine into a liquidShake this liquid well just before you measure a doseMeasure the liquid with a special dose-measuring spoon or medicine cupnot with a regular table spoonIf you do not have a dose-measuring deviceask your pharmacist for one.

Mutagenicity assays did not reveal any valsartan-related effects at either the gene or chromosome levelThese assays included bacterial mutagenicity tests with SalmonellaAmesand E colia gene mutation test with Chinese hamster V79 cellsa cytogenetic test with Chinese hamster ovary cellsand a rat micronucleus test.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of valsartan.

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