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In vitro studies with trophozoites of Entamoeba histolytica have demonstrated that chloroquine also possesses amebicidal activity comparable to that of emetine.

Since this drug is known to concentrate in the liverit should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

Chloroquine undergoes appreciable degradation in the bodyThe main metabolite is desethylchloroquinewhich accounts for one fourth of the total material appearing in the urinebisdesethylchloroquinea carboxylic acid derivativeand other metabolic products as yet uncharacterized are found in small amountsSlightly more than half of the urinary drug products can be accounted for as unchanged chloroquine.

Chloroquine phosphate is used occasionally to decrease the symptoms of rheumatoid arthritis and to treat systemic and discoid lupus erythematosussclerodermapemphiguslichen planuspolymyositissarcoidosisand porphyria cutanea tardaTalk to your doctor about the possible risks of using this drug for your condition.

What should I discuss with my healthcare provider before taking chloroquineAralen Phosphate

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for malaria prevention include lariam, doxycycline, atovaquone proguanil, hydroxychloroquine, and chloroquine.

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