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Imuran can potentiate the neuromuscular blockade produced by depolarising agents such as succinylcholine and can reduce the blockade produced by non-depolarising agents such as tubocurarineThere is considerable variation in the potency of this interaction.

Imuran therapy should not be initiated in patients who may be pregnantor who are likely to become pregnant without careful assessment of risk versus benefitsee Special Warnings and Precautions for UsePregnancy and Lactation

IMURAN can cause fetal harm when administered to a pregnant womanIMURAN should not be given during pregnancy without careful weighing of risk versus benefitWhenever possibleuse of IMURAN in pregnant patients should be avoidedThis drug should not be used for treating rheumatoid arthritis in pregnant women12.

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