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This medicinal product contains lactosePatients with rare hereditary problems of galactose intolerancethe Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Losartan is a synthetic oral angiotensin-II receptortype AT 1antagonistAngiotensin IIa potent vasoconstrictoris the primary active hormone of the renin/angiotensin system and an important determinant of the pathophysiology of hypertensionAngiotensin II binds to the AT 1 receptor found in many tissuese.gvascular smooth muscleadrenal glandkidneys and the heartand elicits several important biological actionsincluding vasoconstriction and the release of aldosteroneAngiotensin II also stimulates smooth muscle cell proliferation.

Some antihypertensive drugs have smaller blood pressure effectsas monotherapyin black patientsand many antihypertensive drugs have additional approved indications and effectse.gon anginaheart failureor diabetic kidney diseaseThese considerations may guide selection of therapy.

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