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Levothroid should be taken at least 4 hours apart from drugs that are known to interfere with its absorption see precautions, drug interactions .

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Levothyroxine is also effective in the suppression of pituitary TSH secretion in the treatment or prevention of various types of euthyroid goitersincluding thyroid nodulesHashimoto’s thyroiditismultinodular goiter andas adjunctive therapy in the management of thyrotropin-dependent well-differentiated thyroid cancersee INDICATIONS AND USAGEPRECAUTIONSDOSAGE AND ADMINISTRATION

The mechanisms by which thyroid hormones exert their physiologic actions are not completely understoodbut it is thought that their principal effects are exerted through control of DNA transcription and protein synthesisT 3 and T 4 diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNAThis hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins.

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