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Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.

Control of high blood pressure should be part of comprehensive cardiovascular risk managementincludingas appropriatelipid controldiabetes managementantithrombotic therapysmoking cessationexerciseand limited sodium intakeMany patients will require more than one drug to achieve blood pressure goalsFor specific advice on goals and managementsee published guidelinessuch as those of the National High Blood Pressure Education Program’s Joint National Committee on PreventionDetectionEvaluationand Treatment of High Blood PressureJNC

The CHMP has recommended that no dose adjustments for Norvasc are required when used together with the following antihypertensive medicinesthiazidebeta blockersand angiotensin-converting enzymeACEinhibitors.

Choosing to participate in a study is an important personal decisionTalk with your doctor and family members or friends about deciding to join a studyTo learn more about this studyyou or your doctor may contact the study research staff using the contacts provided belowFor general informationLearn About Clinical Studies.

Numerous antihypertensive drugsfrom a variety of pharmacologic classes and with different mechanisms of actionhave been shown in randomized controlled trials to reduce cardiovascular morbidity and mortalityand it can be concluded that it is blood pressure value pharmaceuticals. reductionand not some other pharmacologic property of the drugsthat is largely responsible for those benefitsThe largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of strokebut reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.

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