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Rizact md should not be prescribed to propranolol-treated pediatric patients who weigh less than 40 kg 88 lb .

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RIZACT Tablets are not intended for the prophylactic therapy of migraine or for use in the management of haemiplegic or basilar migraineSafety and effectiveness of RIZACT Tablets have not been established for cluster headachewhich is present in an olderpredominantly male population.

Cases of life-threatening serotonin syndrome have been reported during combined use of selective serotonin reuptake inhibitorsSSRIsor serotonin norepinephrine reuptake inhibitorsSNRIsand triptansThere have been reports describing patients with symptoms compatible with serotonin syndromeincluding altered mental statusautonomic instability and neuromuscular abnormalitiesfollowing the use of SSRIs or serotonin norepinephrine reuptake inhibitorsSNRIsand triptans.

Chemical propertiesrizatriptan may bind to melanin and accumulate in melanin-rich tissuee.geyesover timeThis raises the possibility that rizatriptan could cause toxicity in these tissues after extended useThere werehoweverno adverse ophthalmologic changes related to treatment with rizatriptan in the 1-year dog toxicity studyAlthough no systematic monitoring of ophthalmologic function was undertaken in clinical trials and no specific recommendations for ophthalmologic monitoring are offeredprescribers should be aware of the possibility of long-term ophthalmologic effects.

Life-threatening disturbances of cardiac rhythmincluding ventricular tachycardia and ventricular fibrillation leading to deathhave been reported within a few hours following the administration of 5-HT1 agonistsDiscontinue rizatriptanif these disturbances occur.

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